Llano is located about 25 miles (40 km) Southeast of Palmdale in the Antelope Valley portion of Southern California. The town of Pearblossom lies to the West, while the town of Pinon Hills lies to the East. Pearblossom Highway (State Route 138) runs through the heart of Llano and is its principal street.
Llano was once the home of English writer Aldous Huxley. At the turn of the 20th century there were socialist colonies in Llano, the most notable being Job Harriman's Llano Del Rio commune. The ruins of Llano Del Rio are still extant along Highway 138 east of 165th Street East.