According to the U.S. Census Bureau, the city has a total area of 11.0 square miles (28.4 km2), of which 10.5 square miles (27.3 km2) is land and 0.46 square miles (1.2 km2), or 4.07%, is water. Lake Jackson lies on the state line, half in Florala. Florala State Park occupies all of the lake's
The name Florala refers to the town's location, adjacent to the Florida border: it combines the beginning letters in the words "Florida" and "Alabama".
In 1818, Andrew Jackson stopped at the lake with his soldiers, and thus Lake Jackson is named after him. Since 1870, Florala has served as the home of the world's oldest consecutive annual Masonic Day celebration, through Florala's Fidelity Masonic Lodge #685 (beginning with Chapel Hill and Lake City Lodge #377), and Chapter #441 of the Order of the Eastern Star. The celebration is in honor of St. John's Day, June 24, 1717, when the first Grand Masonic Lodge in England was established. The celebration is held each year on the Friday before the 24th of June and concluding on the Saturday after the 24th.