As of the census of 2000, there were 140 people, 37 households, and 29 families residing in the CDP. The population density was 977.3 people per square mile (386.1/km²). There were 44 housing units at an average density of 307.1/sq mi (121.3/km²). The racial makeup of the CDP was 35.71% White, 8.57% Native American, 5.71% Asian, 49.29% from other races, and 0.71% from two or more races. Hispanic or Latino of any race were 63.57% of the population.
There were 37 households out of which 48.6% had children under the age of 18 living with them, 54.1% were married couples living together, 13.5% had a female householder with no husband present, and 21.6% were non-families. 10.8% of all households were made up of individuals and 8.1% had someone living alone who was 65 years of age or older. The average household size was 3.78 and the average family size was 4.38.
In the CDP the population was spread out with 39.3% under the age of 18, 14.3% from 18 to 24, 30.0% from 25 to 44, 8.6% from 45 to 64, and 7.9% who were 65 years of age or older. The median age was 22 years. For every 100 females there were 125.8 males. For every 100 females age 18 and over, there were 129.7 males.
The median income for a household in the CDP was $23,750, and the median income for a family was $27,500. Males had a median income of $15,625 versus $16,250 for females. The per capita income for the CDP was $8,244. There were 18.8% of families and 20.2% of the population living below the poverty line, including 17.0% of under eighteens and none of those over 64.
In the state legislature Macdoel is located in the 4th Senate District, represented by Republican Sam Aanestad, and in the 2nd Assembly District, represented by Republican Doug LaMalfa. Federally, Macdoel is located in California's 2nd congressional district, which has a Cook PVI of R +13 and is represented by Republican Wally Herger.