The unincorporated community of Paicines is located at 680 feet (207 m) above mean sea level (AMSL) in San Benito County, California along State Route 25. Guide signs along SR25 say the community is 13 miles (21 km) south of Hollister. The community is at the intersection of Panoche Road and SR25. Bolado County Park is just over three miles (5 km) north of the community and the site of the San Benito County Fair.
Hydrologic features in the area include Tres Pinos Creek, the San Benito River, and an unnamed reservoir. The area is in the San Andreas Rift Zone, a term used to describe areas on proximity to the San Andreas Fault. Areas to the south and east are mountainous. The county line runs along the Gabilan Range.
The ZIP Code is 95043. The community is inside area code 831.
In the state legislature Paicines is located in the 12th Senate District, represented by Republican Jeff Denham, and in the 28th Assembly District, represented by Democrat Anna M. Caballero. Federally, Paicines is located in California's 17th congressional district, which has a Cook PVI of D +17 and is represented by Democrat Sam Farr.