As of the census of 2000, there were 2,586 people, 651 households, and 557 families residing in the CDP. The population density was 833.7 people per square mile (322.1/km²). There were 723 housing units at an average density of 233.1/sq mi (90.0/km²). The racial makeup of the CDP was 32.87% White, 4.22% African American, 1.74% Native American, 0.19% Asian, 0.08% Pacific Islander, 56.34% from other races, and 4.56% from two or more races. Hispanic or Latino of any race were 68.17% of the population.
There were 651 households out of which 54.1% had children under the age of 18 living with them, 57.8% were married couples living together, 18.0% had a female householder with no husband present, and 14.3% were non-families. 11.1% of all households were made up of individuals and 5.7% had someone living alone who was 65 years of age or older. The average household size was 3.96 and the average family size was 4.21.
In the CDP the population was spread out with 39.9% under the age of 18, 12.8% from 18 to 24, 25.3% from 25 to 44, 14.7% from 45 to 64, and 7.3% who were 65 years of age or older. The median age was 24 years. For every 100 females there were 113.5 males. For every 100 females age 18 and over, there were 108.7 males.
The median income for a household in the CDP was $23,304, and the median income for a family was $23,750. Males had a median income of $25,855 versus $20,000 for females. The per capita income for the CDP was $8,674. About 42.7% of families and 43.2% of the population were below the poverty line, including 53.0% of those under age 18 and 32.0% of those age 65 or over.
In the state legislature Pixley is located in the 16th Senate District, represented by Democrat Dean Florez, and in the 30th Assembly District, represented by Democrat Nicole Parra. Federally, Pixley is located in California's 21st congressional district, which has a Cook PVI of R +13 and is represented by Republican Devin Nunes.