|St. Matthews, South Carolina|
Location of St. Matthews, South Carolina
St. Matthews is located in the center of Calhoun County at (33.664734, -80.778976). U.S. Route 601 passes through the town, leading northeast 51 miles (82 km) to Camden and southwest 13 miles (21 km) to Orangeburg. South Carolina Highway 6 crosses US 601 in the center of town and leads west 7 miles (11 km) toInterstate 26 and southeast 22 miles (35 km) to Interstate 95 near Santee.
According to the United States Census Bureau, St. Matthews has a total area of 1.93 square miles (4.99 km2), of which 1.92 square miles (4.97 km2) is land and 0.01 square miles (0.02 km2), or 0.35%, is water.