Sheldon is an unincorporated community in Beaufort County, South Carolina, United States, at latitude 32.602 and longitude -80.793. Sheldon is located approximately halfway between Beaufort and Yemassee and just east ofInterstate 95 in the heart of the Lowcountry region. U.S. Highway 17 and U.S. Highway 21 run through the center of the community in a wrong-way concurrency.
A rural area in character, Sheldon was primarily a common gathering area for various plantation owners and slaves prior to the Civil War. It is renowned for the Old Sheldon Church Ruins. Several hunt clubs and gated communities are located in the area.
The Pocosobo Town was listed on the National Register of Historic Places in 1994.